transcription factor Sp1 (SP1, TSFP1)
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Function
- recognizes & binds to Sp1 sites
- one of the transcription factors that is directly influenced by reactive oxygen species & proinflammatory cytokines
- binds to GC box promoters elements & selectively activates mRNA synthesis from genes that contain functional recognition sites
- can interact with G/C-rich motifs from serotonin receptor promoter
- interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF & PHC2
- interacts with varicella-zoster virus IE62 protein & HIV-1 Vpr
Structure
- O-glycosylated; contains N-acetylglucosamine side chains
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment
- nucleus, cytoplasm
- nuclear location is regulated by glycosylation & phosphorylation
- insulin promotes nuclear location
- glucagon promotes cytoplasmic location
Expression
- induced by insulin
- up-regulated in adenocarcinomas of the stomach (at protein level)
More general terms
- redox-modulated transcription factor
- Sp1 transcription factor family
- glycoprotein
- C2H2 type zinc finger protein
- phosphoprotein
Additional terms
References
- ↑ Kadonaga et al Science 242:1566 1988
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 296
- ↑ Berk AJ. Regulation of eukaryotic transcription factors by post- translational modification. Biochim Biophys Acta. 1989 Nov 2;1009(2):103-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2529903
- ↑ Ross CA, McInnis MG, Margolis RL, Li SH. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7689767
- ↑ Lavrovsky Y, Chatterjee B, Clark RA, Roy AK. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol. 2000 Aug;35(5):521-32. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10978675
- ↑ UniProt http://www.uniprot.org/uniprot/P08047.html