protein AATF; apoptosis-antagonizing transcription factor; Rb-binding protein che-1 (AATF, CHE1, DED, HSPC277)

Function

• general inhibitor of the histone deacetylase HDAC1
• binding to the pocket region of RB1
  • displaces HDAC1 from RB1/E2F complexes (putative)
  • activation of E2F target genes
  • cell cycle progression
• binding of SP1
  • displaces HDAC1 from from SP1 bound to promotor
  • displacement of SP1 from the CDKN1A promoter leads to increased expression of CDK inhibitor & blocks cell cycle progression
• antagonizes PAWR mediated induction of aberrant amyloid A4 peptide production in Alzheimer disease (putative)
• binds PAWR, POLR2J, RB1, RBL1, RBL2, SP1, MAPT
• hyperphosphorylated during the G1/S phase transition

Structure

belongs to the AATF family

Compartment

nucleus, nucleolus

Expression

• ubiquitously expressed
• expressed at high levels in brain, heart, kidney, placenta, thymus

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26574
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26574
• OMIM: https://mirror.omim.org/entry/608463
• UniProt: http://www.uniprot.org/uniprot/Q9NY61.html