E2F

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Introduction

E2F family of heterodimeric transcription factors originally identified through its role in transcriptional activation of the adenovirus E2 promoter[4]

Function

Structure

Pathology

More general terms

More specific terms

Additional terms

References

  1. Mudryj M, Hiebert SW, Nevins JR. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 1990 Jul;9(7):2179-84. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2141565
  2. Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol. 1994 Dec;14(12):8420-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7969176
  3. 3.0 3.1 3.2 Enoch T, Norbury C. Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biochem Sci. 1995 Oct;20(10):426-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533157
  4. 4.0 4.1 4.2 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168