E2F
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Introduction
E2F family of heterodimeric transcription factors originally identified through its role in transcriptional activation of the adenovirus E2 promoter[4]
Function
- E2F forms a DNA-binding complex with DP-1 (DRTF1) & binds DNA through the E2 recognition site, 5'-TTTC[CG]CGC-3'
- E2F binds to Rb protein[3]
- cyclin-dependent kinase (CDK)-mediated phosphorylation of Rb dissociates the Rb-E2F complex, freeing E2F to facilitate transcription of S-phase specific genes[3]
Structure
- E2F family of heterodimeric transcription factors E2F1, E2F2, E2F3 & presumably E2F4 all contain a DNA-binding-domain in the central part of the molecule & C-terminal Rb-binding domain
Pathology
- viral oncoproteins, notably E1A, T-antigen & HPV E7, are capable of sequestering RB protein, thus releasing active E2F complexes
- E2F binds to & activates the adenovirus E2 promoter[4]
More general terms
More specific terms
- transcription factor E2F1; E2F-1; PBR3; PRB-binding protein E2F-1; retinoblastoma-associated protein 1; RBAP-1; retinoblastoma-binding protein 3; RBBP-3 (E2F1, RBBP3)
- transcription factor E2F2 (E2F-2, E2F2)
- transcription factor E2F3 (E2F-3, E2F3, KIAA0075)
- transcription factor E2F4 (E2F-4, E2F4)
- transcription factor E2F5 (E2F-5, E2F5)
- transcription factor E2F6 (E2F-6, E2F6)
- transcription factor E2F8 (E2F-8, E2F8)
Additional terms
References
- ↑ Mudryj M, Hiebert SW, Nevins JR. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 1990 Jul;9(7):2179-84. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2141565
- ↑ Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol. 1994 Dec;14(12):8420-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7969176
- ↑ 3.0 3.1 3.2 Enoch T, Norbury C. Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biochem Sci. 1995 Oct;20(10):426-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533157
- ↑ 4.0 4.1 4.2 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168