adenovirus oncoprotein E1a

^[1]^[2]^[3]

Pathology

interferes with cAMP-dependent activity of CREB
binding to:
- transcriptional activator proteins
- transcriptional adaptor proteins:
  - EP300
adenovirus E1a alone initiates transformed foci in cell cultures, but fails to sustain these foci which undergo apoptosis
E1b when coexpressed with E1a, efficiently induces transformation^[2]
over-expression of bcl-2 can also cooperate with E1a in inducing transformation^[2]
interacts with CTBP1, CTBP2 (via C-terminus)
- disrupts the interaction of CTBP1 with RBBP8
cellular targets of the adenovirus oncoprotein E1A include:
- E4F1
- EP300

↑ Arany Z, Newsome D, Oldread E, Livingston DM, Eckner R. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature. 1995 Mar 2;374(6517):81-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7870178 1995
↑ ^2.0 ^2.1 ^2.2 Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7742-6. Erratum in: Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9974. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1457005
↑ UniProt http://www.uniprot.org/uniprot/Q13363.html