C-terminal-binding protein 1 (CtBP1, CTBP)
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Function
- equilibrium between tubular & stacked structures in Golgi
- co-repressor targeting diverse transcription regulators, including GLIS2
- dehydrogenase activity
- interacts with the C-terminus of adenovirus E1A protein, ELK3 & CTIP via their consensus motif P-X-[DNS]-L-[STVA]
- can form homodimers or heterodimers of CTBP1 & CTBP2
- interacts with FOXP2, HIPK2, PNN, NRIP1
- component of large corepressor complex
- phosphorylation regulated during the cell cycle
- phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation
- ADP-ribosylated; when cells are exposed to brefeldin-A (BFA)
- functions in brown adipose tissue differentiation
- phosphorylated upon DNA damage, probably by ATM or ATR.
- sumoylation on Lys-428 is promoted by E3 SUMO-protein ligase CBX4
- homodimer or heterodimer
- heterodimer with CTBP2
- interacts with PRDM16
- interaction represses white adipose tissue-specific gene expression
- interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 & ZNF217 (putative)
- interacts with ELK3 (via its PXDLS motif)
- interacts with RBBP8 (via its PXDLS motif)
- interaction is disrupted by binding to adenovirus E1A
- interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B & WIZ
- interaction with SATB1 (non-acetylated form)
- interaction stabilizes its attachment to DNA & promotes transcription repression
Compartment
Alternative splicing
named isoforms=2
Pathology
- interacts with adenovirus E1A protein (via its C-terminus)
- interaction disrupts the interaction of CTBP1 with RBBP8
- interacts with Epstein-Barr virus EBNA3 & EBNA6