DNA-binding protein SATB1; special AT-rich sequence-binding protein 1 (SATB1)

Function

• binds to DNA at special AT-rich sequences at nuclear matrix or scaffold-associated regions
• thought to recognize the sugar-phosphate structure of double-stranded DNA
• sumoylated

Structure

• belongs to the CUT homeobox family
• contains 2 CUT DNA-binding domains
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

expressed predominantly in thymus

More general terms

• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01826.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6304
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6304
• OMIM: https://mirror.omim.org/entry/602075