nuclear receptor-interacting protein 1; nuclear factor RIP140; receptor-interacting protein 140 (NRIP1)

Function

• modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 & ESR1
• also modulates transcriptional repression by nuclear hormone receptors
• interacts with the ligand binding domain (LBD) of NR2C1 in the absence of ligand
• interacts with RARA & RXRB homodimers & RARA/RXRB heterodimers in the presence of ligand
• interacts with HDAC1 & HDAC3 via its N-terminal domain (putative)
• interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR3C1, NR3C2, YWHAH, JUN & FOS
• found in a complex with both NR3C1 & YWHAH
• acetylation regulates its nuclear translocation & corepressive activity (putative)
• acetylation abolishes interaction with CTBP1
• phosphorylation enhances interaction with YWHAH

Structure

• contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors
• the C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR & RXRB homo- & heterodimers, for the corepressor activity, & for the formation of an HDAC3 complex with RARA/RXRB (putative)
• contains at least four autonomous repression domains (RD1-4)
  • RD1 functions via a histone deacetylase (HDAC)-independent mechanism
  • RD2, RD3 & RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type
  • RD2 is dependent on CTBP binding

Compartment

• nucleus
• localized to discrete foci
• redistributes to larger nuclear domains upon binding to ligand-bound NR3C1

Pathology

• genetic variation in NRIP1 may act as predisposing factor for endometriosis

More general terms

• nuclear protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8204
• OMIM: https://mirror.omim.org/entry/602490
• UniProt: http://www.uniprot.org/uniprot/P48552.html