nuclear receptor subfamily 2 group C member 1; orphan nuclear receptor TR2; testicular receptor 2 (NR2C1, TR2)

Function

• orphan nuclear receptor
• represses transcription & binds DNA as a homodimer
• binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism
• interacts with NRIP1
• directly interacts with HDAC3 & HDAC4 via the DNA-binding domain (putative)

Structure

• homodimer
• belongs to the nuclear hormone receptor family, NR2 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

More general terms

• steroid receptor
• zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/601529
• UniProt: http://www.uniprot.org/uniprot/P13056.html