histone deacetylase 4 (HDAC4)

Function

• see histone deacetykase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• involved in muscle maturation via its interaction with myocyte enhancer factors, including MEF2A, MEF2C & MEF2D
• interacts with HDAC7 (putative)
• interacts with MEF2C & NR2C1
• interacts with a 14-3-3 chaperone protein (phosphorylation dependent)
• interacts with BTBD14B
• interacts with JARID1B
• phosphorylated by CaMK4 at Ser-246, Ser-467 & Ser-632
• phosphorylation at other residues is required for interaction with 14-3-3
• sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, & prevented by phosphorylation by CaMK4

Structure

• homodimer, homodimerization via its N-terminal domain
• nuclear export sequence mediates shuttling between nucleus & cytoplasm
• belongs to the histone deacetylase family, type 2 subfamily

Compartment

• nucleus, cytoplasm
• shuttles between nucleus & cytoplasm
• upon muscle cells differentiation, accumulates in nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation
• export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein & its phosphorylation at Ser-246, Ser-467 & Ser-632 by CaMK4
• nuclear localization probably depends on sumoylation

Expression

ubiquitous

More general terms

• histone deacetylase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P56524.html
• OMIM: https://mirror.omim.org/entry/605314
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9759