Ca+2/calmodulin-dependent protein kinase 4 (CaM kinase 4, CAM kinase-GR, CAMK4)

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Function

Ca+2/calmodulin-dependent protein kinase
role in Ca+2-triggered signaling cascade
may be involved in transcriptional regulation
may be involved in regulation of microtubule dynamics
in vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D & STMN1/OP18
may be involved in spermatogenesis
may play a role in the consolidation/retention of hippocampus-dependent long-term memory (putative)
activated by Ca+2/calmodulin
binding of calmodulin may releave intrasteric autoinhibition
must be phosphorylated to be maximally active
phosphorylated by CAMKK1 or CAMKK2
autophosphorylation of the N-terminus is required for full activation
in part, activity is independent on Ca+2/calmodulin & autophosphorylation of Ser-336 allows to switch to a Ca+2/calmodulin-independent state (putative)
probably inactivated protein phosphatase 2A
dephosphorylated by protein phosphatase 2A, probably on Thr-200
autophosphorylated & phosphorylated by CAMKK1 & CAMKK2 (putative)

monomer (putative)
interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB
interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca+2/calmodulin
belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. CaMK subfamily
contains 1 protein kinase domain

restricted to brain in rat; appears after birth