Ca+2/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Ca+2/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha (CAMKK1, CAMKKA)

Function

• Ca+2/calmodulin-dependent protein kinase
• component of a Ca+2-triggered signaling cascade
• phosphorylates CAMK1, CAMK1D, CAMK1G & CAMK4
• role in regulating cell apoptosis
• promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death
• activated by Ca+2/calmodulin
• binding of calmodulin may relieve autoinhibition
• partially inhibited upon phosphorylation by PRCAKA/PKA (putative)
• may be regulated through phosphorylation by CAMK1 & CAMK4
• appears to be autophosphorylated (Ca+2/calmodulin-dependent)
• phosphorylated at multiple sites by PRCAKA/PKA
• phosphorylation of Ser-458 is blocked upon binding to Ca+2/calmodulin
• in vitro, phosphorylated by CAMK1 & CAMK4
• interacts with CAMK4 & calmodulin (putative)

Structure

• autoinhibitory domain overlaps with the calmodulin- binding region & may be involved in autoinhibition
• the RP domain (Arg/Pro-rich) is involved in recognition of CAMK1 & CAMK4 as substrates (putative)
• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• cytoplasm, nucleus ( putative)

Alternative splicing

named isoforms=2

More general terms

• Ca+2/calmodulin-dependent protein kinase [CaM kinase] kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84254
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84254
• OMIM: https://mirror.omim.org/entry/611411
• UniProt: http://www.uniprot.org/uniprot/Q8N5S9.html