Ca+2/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM kinase ID; CaM-KI delta; CaMKI delta; CaMKID; CaMKI-like protein kinase; CKLiK (CAMK1D, CAMKID)

^[1]

Function

Ca+2/calmodulin-dependent protein kinase
operates in the Ca+2-triggered CaMKK-CaMK1 signaling cascade &, upon Ca+2 influx
- activates CREB-dependent gene transcription
- regulates Ca+2-mediated granulocyte function & respiratory burst
- regulates basal dendritic growth of hippocampal neurons
in neutrophils, required for cytokine-induced proliferative responses & activation of the respiratory burst
phosphorylates transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei=
may play a role in apoptosis of erythroleukemia cells
in vitro, phosphorylates transcription factor CREM isoform beta
activated by Ca+2/calmodulin
binding of calmodulin results in conformational change that relieves autoinhibition & allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2
phosphorylation of Thr-180 results in several fold increase in total activity
unlike CaMK4, may be unable to exhibit autonomous activity after Ca+2/calmodulin activation

the autoinhibitory domain overlaps with the calmodulin binding region & interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (putative)
belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
contains 1 protein kinase domain

cytoplasm, nucleus (probable)
predominantly cytoplasmic
nuclear localization increases upon activation by KCl treatment in hippocampal neurons

widely expressed
highly & mostly expressed in polymorphonuclear leukocytes (neutrophils & eosinophils)
little or no expression in monocytes or lymphocytes
expressed during hippocampal formation
- high expression in the pyramidal cell layers
induced expression increases upon treatment of EC cells with DMSO & retinoic acid
induced by KCL in PC12 cells