Ca+2/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; Ca+2/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta (CAMKK2, CAMKKB, KIAA0787)

Function

• Ca+2/calmodulin-dependent protein kinase
• component of a Ca+2-triggered signaling cascade
• isoforms 1, 2 & 3 phosphorylate CAMK1 & CAMK4
• isoform 3 phosphorylates CAMK1D
• isoforms 4, 5 & 6 lack part of the calmodulin-binding domain & are inactive
• seems to be involved in hippocampal activation of CREB1
• activated by Ca+2/calmodulin
• binding of calmodulin may relieve autoinhibition
• autophosphorylation does not alter activity or regulation by Ca+2/calmodulin
• in part, activity is independent on Ca+2/calmodulin (putative)
• autophosphorylated (putative)
• interacts with calmodulin (putative)

Structure

• autoinhibitory domain overlaps with calmodulin-binding domain & may be involved in autoinhibition
• the RP domain (Arg/Pro-rich) is involved in recognition of CAMK1 & CAMK4 as substrates (putative)
• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=7

Expression

• ubiquitously expressed
• expressed in brain > spleen, prostate, thyroid & leukocytes > lung

More general terms

• Ca+2/calmodulin-dependent protein kinase [CaM kinase] kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10645
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10645
• UniProt: http://www.uniprot.org/uniprot/Q96RR4.html