Ca+2/calmodulin-dependent protein kinase [CaM kinase] 1 (CaM kinase 1-alpha, CAMK1)

Function

• Ca+2/calmodulin-dependent protein kinase
• role in Ca+2-triggered signaling cascade involved cellular processes including transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization & neurite outgrowth
• involved in Ca+2-dependent activation of the ERK pathway (putative)
• recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]
• phosphorylates EIF4G3/eIF4GII
• in vitro phosphorylates CREB1, ATF1, CTFR, MYL9, SYN1/synapsin-1 & SYNII/synapsin-2 (putative)
• activated by Ca+2/calmodulin
• binding of calmodulin results in a conformational change that generates functional binding sites for both substrate & ATP, thus releaves intrasteric autoinhibition
• must be phosphorylated to be maximally active
• phosphorylated by CAMKK1 or CAMKK2

Structure

• monomer
• interacts with XPO1 (putative)
• autoinhibitory domain overlaps with the calmodulin binding region & interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (putative)
• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic (putative)

Expression

ubiquitous

More general terms

• Ca+2/calmodulin-dependent protein kinase (CaM kinase)

Database

• UniProt: http://www.uniprot.org/uniprot/Q14012.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8536
• OMIM: https://mirror.omim.org/entry/604998