exportin-1; exp1; chromosome region maintenance 1 protein homolog (XPO1, CRM1)

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Function

component of nuclear export complex
- mediates nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NED
- mediates nuclear export of RNAs
U3 snoRNA transport from Cajal bodies to nucleoli
binds to late precursor U3 snoRNA bearing a TMG cap
in the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein & to the GTPase RAN in its active GTP-bound form (Ran-GTP)
docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins
upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex & hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 & RANGAP1, respectively) cause release of cargo from the export receptor
directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- & GDP-bound forms of Ran between the cytoplasm & nucleus
phosphorylated upon DNA damage, probably by ATM or ATR
found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 & m7G-capped RNA (putative)
found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1
interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 & TERT
interacts with NEMF (via its N-terminus)
interacts with the monomeric form of BIRC5/survivin deacetylated at Lys-129

several viruses, among them HIV-1, HTLV-1 & influenza A highjack XPO1 to export their unspliced or incompletely spliced RNAs out of the nucleus
mediates nuclear export of HIV-1 Rev & HTLV-1 Rex proteins
role in HTLV-1 Rex multimerization
found in a complex with HIV-1 Rev, HIV-1 Rev response element RNA, Ran
found in a complex with HTLV-1 Rex, RANBP3, Ran
interacts with Epstein- Barr virus BMLF1