GTP-binding nuclear protein Ran; GTPase Ran; Ras-related nuclear protein; Ras-like protein TC4; androgen receptor-associated protein 24; spi1 protein (RAN, ARA24, OK/SW-cl81)
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Function
- nucleocytoplasmic transport
- chromatin condensation
- cell cycle control
- enhances androgen receptor (AR) mediated transactivation;
- interacts with AR N-terminal poly-Gln region
- interaction with AR is inversely correlated with the poly-Gln length
- forms a complex with CHC1
- part of a complex consisting of RANBP9, Ran, DYRK1B & COPS5
- found in a nuclear export complex with RANBP3 & XPO1
- component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN & XPO1
- found in a trimeric export complex with SNUPN, Ran & XPO1
- interacts with RANBP10
Structure
Compartment
- nucleus,cytoplasm. melanosome
- becomes dispersed throughout the cytoplasm during mitosis
- in melanosome fractions from stage 1 to stage 4
Expression
expressed in a variety of tissues
Pathology
- in HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) & XPO1
- found in a complex with HTLV-1 Rex, RANBP3 & XPO1
More general terms
References
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Scheffzek K, Klebe C, Fritz-Wolf K, Kabsch W, Wittinghofer A. Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form. Nature. 1995 Mar 23;374(6520):378-81. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7885480 (crystal structure)
- ↑ UniProt http://www.uniprot.org/uniprot/P17080.html