snurportin-1 (RNA U transporter 1, SNUPN, RNUT1, SPN1)

Function

• U snRNP-specific nuclear import adapter
• trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs
• binds specifically to the terminal m3G-cap U snRNAs
• component of an import snRNP complex
• component of a nuclear export receptor complex
• interacts with DDX20, IPO7, KPNB1, SMN1, SNRPB & XPO1
• interacts directly with XPO1
  • interaction with XPO1 & binding to m3G-cap U snRNPs are mutually exclusive (putative)
• nucleoplasmic shuttling protein
  • nuclear import involves the nucleocytoplasmic transport receptor importin beta
  • reexported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway

Compartment

nucleus, cytoplasm

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/607902
• UniProt: http://www.uniprot.org/uniprot/O95149.html