ATP-dependent RNA helicase DDX20; DEAD box protein 20; DEAD box protein DP 103; component of gems 3; Gemin-3 (DDX20, DP103, GEMIN3)

Function

• component of the SMN complex
• may also play a role in the metabolism of snoRNPs
• interacts directly with SMN1 & with several spliceosomal snRNP core Sm proteins, including SNUPN, SNRPB, SNRPD2 & SNRPD3
• interacts with PPP4R2
• interacts with EBV EBNA2 & EBNA3C
• interacts with FOXL2

Structure

• belongs to the DEAD box helicase family, DDX20 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain

Compartment

• cytoplasm. nucleus, gem
• localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems)

Expression

ubiquitous

More general terms

• DEAD box ATP-dependent helicase
• phosphoprotein

Component of

• SMN complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11218
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11218
• OMIM: https://mirror.omim.org/entry/606168
• UniProt: http://www.uniprot.org/uniprot/Q9UHI6.html