serine/threonine protein phosphatase 4 regulatory subunit 2 (PPP4R2)

Function

• regulatory subunit of serine/threonine protein phosphatase 4 (PPP4C)
• may regulate the activity of PPP4C at centrosomal microtubule organizing centers
• interaction with SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs
• interacts with the subunits of the core SMN complex that contains SMN1, DDX20/GEMIN3 & GEMIN4

Structure

belongs to the PPP4R2 family

Compartment

centrosome

Alternative splicing

named isoforms=3

Expression

widely expressed

More general terms

• phosphoprotein
• centrosomal protein
• enzyme regulatory subunit

Component of

• serine/threonine protein phosphatase 4 (PP4)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NY27.html