serine/threonine protein phosphatase 4 catalytic subunit; PP4C; Pp4; protein phosphatase X; PP-X (PPP4C, PPP4, PPX)

Function

• protein phosphatase-4 cataytic subuunit
• occurs in different assemblies of the catalytic & one or more regulatory subunits
• interacts with REL, NFKB1/p50 & RELA
• interacts with SMN1 & GEMIN4
• interacts with IRS4 (phosphorylated)
• interacts with SMEK1/PPP4R3A; interaction requires PP4R2
• interacts with HDAC3

Cofactor:

• binds 1 Fe+2/Fe+3 per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

Structure

• belongs to the PPP phosphatase family, PP-4 (PP-X) subfamily

Compartment

cytoplasm. nucleus, centrosome

More general terms

• serine/threonine phosphatase
• enzyme catalytic subunit

Component of

• serine/threonine protein phosphatase 4 (PP4)

Database

• UniProt: http://www.uniprot.org/uniprot/P60510.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5531
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5531
• OMIM: https://mirror.omim.org/entry/602035