dual specificity tyrosine-phosphorylation-regulated kinase 1B; minibrain-related kinase; Mirk protein kinase (DYRK1B, MIRK)

Function

• dual-specificity kinase
• has both Ser/Thr kinase & tyrosine kinase activities
• enhances transcriptional activity of TCF1/HNF1A & FOXO1
• inhibits epithelial cell migration
• autophosphorylated on Tyr
• phosphorylated by MAP kinase
• Tyr phosphorylation may be required for dimerization
• interacts with DCOHM, MAP2K3/MKK3, RANBP9 & TCF1/HNF1A
• part of a complex consisting of RANBP9, RAN, DYRK1B & COPS5
• interacts with DCAF7

Inhibition:

• homodimer
• inhibited by RANBP9

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily
• contains 1 protein kinase domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• highest expression in skeletal muscle, testis, heart & brain
• low expression in colon, lung
• expressed in a variety of tumor cell lines

Pathology

• mediates colorectal carcinoma cell survival in mitogen-poor environments

More general terms

• dual-specificity tyrosine-phosphorylation regulated kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9149
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9149
• OMIM: https://mirror.omim.org/entry/604556
• UniProt: http://www.uniprot.org/uniprot/Q9Y463.html