Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor (PCBD2, DCOH2, DCOHM)

Function

• tetrahydrobiopterin biosynthesis
• prevents formation of 7-pterins
• accelerates formation of quinonoid-BH2
• regulates dimerization of homeodomain protein HNF1-alpha & enhances its transcriptional activity
• interacts with DYRK1B

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-  5,6,7,8-tetrahydro-4a-hydroxypterin

                  PCBD2
                  <--->

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin +   H2O

Structure

• homotetramer
• belongs to the pterin-4-alpha-carbinolamine dehydratase family

More general terms

• hydro-lyase, hydratase or dehydratase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H0N5.html