DDB1- & CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog (DCAF7, HAN11, WDR68)

Function

• role in craniofacial development
• acts upstream of the EDN1 pathway
• required for formation of the upper jaw equivalent, the palatoquadrate
• activity required for EDN1 pathway function differs between 1st & 2nd arches
• associates with DIAPH1; controls GLI1 transcriptional activity
• could be involved in skin development
• may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
• protein modification; protein ubiquitination
• interacts with DYRK1A, DYRK1B & DIAPH1
• interacts with DDB1

Structure

• belongs to the WD repeat DCAF7 family
• contains 4 WD repeats

Compartment

• cytoplasm. nucleus
• overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm

More general terms

• nuclear protein
• WD repeat protein family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10238
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10238
• OMIM: https://mirror.omim.org/entry/605973
• UniProt: http://www.uniprot.org/uniprot/P61962.html