WD repeat protein family

Introduction

Contains highly conserved repeating units usually ending with Trp-Asp. Found in eukaryotes, but not prokaryotes. Involved in signal transduction, RNA processing, gene regulation, development, vesicular traffic, regulation of cytoskeletal assembly & the cell cycle.

More general terms

• protein family member

More specific terms

• actin-related protein 2/3 complex subunit 1A; SOP2-like protein (ARPC1A, SOP2L)
• actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kD subunit; p41-ARC (ARPC1B, ARC41)
• activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1, KIAA1736)
• aladin (adracalin, AAAS, ADRACALA, GL003)
• apoptotic protease-activating factor 1; APAF-1 (APAF1, KIAA0413)
• autophagy protein 16-like; autophagy-related protein 16-1; APG16-like 1 (ATG16L1, APG16L, UNQ9393/PRO34307)
• autophagy-related protein 16-2 (APG16-like 2, WD repeat-containing protein 80, ATG16L2, WDR80)
• breast carcinoma amplified sequence 3 (GAOB1, Maab1 protein, BCAS3)
• bromodomain & WD repeat domain-containing protein 3 (BRWD3)
• BTB/POZ domain-containing protein KCTD3 (renal carcinoma antigen NY-REN-45, KCTD3)
• cell division cycle protein 20 homolog B (CDC20B)
• cell division cycle protein 20 homolog; p55CDC (CDC20)
• cleavage stimulation factor 50 kD subunit; CSTF 50 kD subunit; CF-1 50 kD subunit; CstF-50 (CSTF1)
• CMT1A duplicated region transcript 1 protein (CDRT1, C17orf1, C17orf1A, HREP)
• coatomer subunit alpha; alpha-coat protein; alpha-COP; HEP-COP; HEPCOP; contains: xenin; xenopsin-related peptide; contains: proxenin (COPA)
• coatomer subunit beta'; beta'-coat protein; beta'-COP; p102 (COPB2)
• constitutive photomorphogenic protein 1 (E3 ubiquitin-protein ligase RFWD2, RING finger & WD repeat domain protein 2, RFWD2)
• coronin
• coronin-7; Crn7; 70 kD WD repeat tumor rejection antigen homolog (CORO7)
• DDB1- & CUL4-associated factor 4; WD repeat-containing protein 21A (DCAF4, WDR21, WDR21A)
• WD repeat-containing protein 68; DDB1- & CUL4-associated factor 7; WD repeat-containing protein An11 homolog (DCAF7, HAN11, WDR68)
• denticleless protein homolog (Lethal(2) denticleless protein homolog, Ddb1- & Cul4-associated factor 2, retinoic-acid regulated nuclear matrix-associated protein, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP)
• DmX-like protein 2; rabconnectin-3 (DMXL2, KIAA0856)
• DNA damage-binding protein 2; damage-specific DNA-binding protein 2; DDB p48 subunit; DDBb; UV-damaged DNA-binding protein 2; UV-DDB 2 (DDB2)
• DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA (ERCC8, CKN1, CSA)
• dynein intermediate chain 1, axonemal (DNAI1)
• dynein intermediate chain 1, cytosolic (DH IC-1, DYNC1I1, DNCI1, DNCIC1,)
• dynein intermediate chain 2, axonemal
• dynein intermediate chain 2, cytosolic (DYNC1I2)
• dystrophia myotonica WD repeat-containing protein (dystrophia myotonica-containing WD repeat motif protein, DMR-N9 protein, protein 59, DMWD, DM9)
• E3 ubiquitin-protein ligase HERC1 (HECT domain & RCC1-like domain-containing protein 1, p532, p619, HERC1)
• E3 ubiquitin-protein ligase LNX; ligand of Numb-protein X 1; Numb-binding protein 1 (LNX1, LNX, UNQ574/PRO1136)
• E3 ubiquitin-protein ligase TRAF7; RING finger & WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 (TRAF7, RFWD1, RNF119)
• Echinoderm microtubule-associated protein-like 1; EMAP-1; HuEMAP-1 (EML1, EMAP1, EMAPL, EMAPL1)
• echinoderm microtubule-associated protein-like 2 (EMAP-2, HuEMAP-2, EML2, EMAP2, EMAPL2)
• Echinoderm microtubule-associated protein-like 3 (EMAP-3, EML3)
• echinoderm microtubule-associated protein-like 4; EMAP-4; restrictedly overexpressed proliferation-associated protein; Ropp 120 (EML4, C2orf2, EMAPL4)
• Echinoderm microtubule-associated protein-like 5 (EMAP-5, EML5)
• EML5L-like protein (EML5LL, EML6)
• enhancer of mRNA-decapping protein 4 (human enhancer of decapping large subunit, Hedls, autoantigen Ge-1, autoantigen RCD-8, EDC4, HEDLS)
• eukaryotic initiation factor 3 subunit 2 (eIF-3 beta, eiF3 p36, TGF-beta receptor-interacting protein-1, trip1, EIF3I)
• eukaryotic translation initiation factor 2A (eIF-2A, 65 kD eukaryotic translation initiation factor 2A, EIF2A)
• F-box & WD-repeat protein
• factor associated with neutral sphingomyelinase activation; protein FAN; factor associated with N-smase activation (NSMAF, FAN)
• Fizzy-related protein homolog; Fzr; Cdh1/Hct1 homolog; hCDH1; CDC20-like protein 1 (FZR1, CDH1, FYR, FZR, KIAA1242)
• glutamate-rich WD repeat-containing protein 1 (GRWD1, GRWD, KIAA1942, WDR28)
• GTP-binding regulatory protein beta
• guanine nucleotide-binding protein subunit beta-2-like 1; guanine nucleotide-binding protein subunit beta-like protein 12.3; receptor of activated protein kinase C 1; RACK1; receptor for activated C kinase; cell proliferation-inducing gene 21 protein; ...
• WD repeat-containing protein 14; sguanine nucleotide-binding protein subunit beta-like protein 1; G protein subunit beta-like protein 1; DGCRK3; WD40 repeat-containing protein deleted in VCFS; WDVCF (GNB1L, GY2, KIAA1645, WDR14, FKSG1)
• histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-rem...
• histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2)
• intraflagellar transport 140 homolog (WD & tetratricopeptide repeats protein 2, IFT140, KIAA0590, WDTC2)
• WD repeat protein 56 (intraflagellar transport 80 homolog, IFT80, KIAA1374, WDR56)
• intraflagellar transport protein 172 homolog (IFT172, KIAA1179)
• jouberin; Abelson helper integration site 1 protein homolog (AHI-1, AHI1)
• Lethal(2) giant larvae protein homolog 1 (LLGL, human homolog to the D-lgl gene, Hugl-1, DLG4, LLGL1, HUGL)
• lethal(2) giant larvae protein homolog 2 (HGL, LLGL2)
• leucine-rich repeat & WD repeat-containing protein 1 (LRWD1)
• Leucine-rich repeat & WD repeat-containing protein KIAA1239 (KIAA1239)
• lipopolysaccharide-responsive & beige-like anchor protein; Beige-like protein; CDC4-like protein (LRBA, BGL, CDC4L, LBA)
• lysosomal-trafficking regulator; Beige homolog (LYST, CHS, CHS1)
• WD repeat protein 77 (methylosome protein 50, MEP50 protein, WDR77, MEP50)
• mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1, JNKBP1, MAPKBP1, JNKBP1, KIAA0596)
• mitotic checkpoint protein BUB3 (budding inhibitied by benzimidazoles, BUB3)
• NACHT & WD repeat domain-containing protein 1 (NWD1)
• NEDD1 protein; neural cell expressed developmentally down-regulated protein 1; NEDD-1 (NEDD1)
• neurobeachin-like protein 2 (NBEAL2 KIAA0540 UNQ253/PRO290)
• neuroblastoma-amplified gene protein (NAG, NBAS)
• notchless protein homolog 1; WD repeat protein HUSSY-07 (NLE1)
• nuclear receptor interaction protein; NRIP; IQ motif & WD repeat-containing protein 1; androgen receptor complex-associated protein (ARCAP, IQWD1, DCAF6)
• nucleolar protein 10 (NOL10)
• p21-activated protein kinase-interacting protein 1; PAK1-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1 (PAK1IP1, PIP1, WDR84)
• partner & localizer of BRCA2 ( PALB2, FANCN)
• periodic tryptophan protein 2 homolog (PWP2H, PWP2)
• peroxisomal targeting signal 2 receptor; PTS2 receptor; peroxin-7 (PEX7 PTS2R)
• PH-interacting protein (PHIP, IRS-1 PH domain-binding protein, WD repeat-containing protein 11, PHIP, WDR11)
• phosphatase-2A 55 kD regulatory subunit B gamma (PP2A, subunit B, B-gamma isoform; PP2A, subunit B, B55-gamma isoform; PP2A, subunit B, PR55-gamma isoform; PP2A, subunit B, R2-gamma isoform; IMYPNO1; PPP2R2C)
• phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4, PI3-kinase p150 subunit, phosphoinositide 3-kinase adaptor protein, PIK3R4)
• phospholipase A-2-activating protein; PLA2P; PLAP (PLAA PLAP)
• platelet-activating factor acetylhydrolase IB subunit alpha; PAF acetylhydrolase 45 kD subunit; PAF-AH 45 kD subunit; PAF-AH alpha; PAFAH alpha; Lissencephaly-1 protein; LIS-1 (PAFAH1B1, LIS1, MDCR, MDS, PAFAHA)
• pleiotropic regulator 1 (PLRG1)
• polycomb protein EED; hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 (EED)
• pre-mRNA-processing factor 19 (PRP19/PSO4 homolog, hPso4, nuclear matrix protein 200, senescence evasion factor, PRPF19, NMP200, PRP19, SNEV)
• prolactin regulatory element-binding protein; mammalian guanine nucleotide exchange factor msec12 (PREB, SEC12)
• protein DmX-like 1; X-like 1 protein (DMXL1, XL1)
• protein neurobeachin; lysosomal-trafficking regulator 2; protein; BCL8 (NBEA, BCL8B, KIAA1544, LYST2)
• protein RIC1 homolog (connexin 43-interacting protein of 150 kD) (KIAA1432 CIP150)
• protein transport protein Sec31A (SEC31-related protein A, SEC31-like 1, ABP125, ABP130, Web1-like protein, SEC31A, KIAA0905, SEC31L1, HSPC275, HSPC334)
• protein transport protein Sec31B; SEC31-related protein B; SEC31B-1; SEC31-like 2 (SEC31B, SEC31L2)
• regulatory-associated protein of mTOR; Raptor; P150 target of rapamycin (TOR)-scaffold protein (RPTOR, KIAA1303)
• retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)
• ribosome biogenesis protein BOP1 (block of proliferation 1 protein, BOP1, KIAA0124)
• RING finger & WD repeat domain-containing protein 3 (RING finger protein 201, RFWD3, RNF201)
• serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD (STRAP, MAWD, UNRIP)
• serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B delta (PP2A, subunit B, B-delta isoform; PP2A, subunit B, B55-delta isoform; PP2A, subunit B, PR55-delta isoform; PP2A, subunit B, R2-delta isoform, PPP2R2D, KIAA1541)
• SH3KBP1-binding protein 1 (SHKBP1)
• sperm-associated antigen 16 protein (Pf20 protein homolog, SPAG16, PF20)
• stat3-interacting protein (StIP1, ELP2, SHINC-2, STATIP1)
• sterol regulatory element-binding protein cleavage-activating protein; SREBP cleavage-activating protein; SCAP (SCAP, KIAA0199, PSEC0227)
• striatin (STRN)
• striatin-3; cell cycle autoantigen SG2NA; S/G2 antigen (STRN3, GS2NA, SG2NA)
• striatin-4; zinedin (STRN4 ZIN)
• syntaxin-binding protein 5-like (tomosyn-2, lethal[2] giant larvae protein homolog 4, STXBP5L, KIAA1006, LLGL4)
• TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kD subunit 5L; PCAF-associated factor 65-beta; PAF65-beta (TAF5L, PAF65B)
• target of rapamycin complex subunit LST8; TORC subunit LST8; G protein beta subunit-like; Gable; protein GbetaL; mammalian lethal with SEC13 protein 8; mLST8 (MLST8, GBL, LST8)
• Tectonin beta-propeller repeat-containing protein 2; WD repeat-containing protein KIAA0329/KIAA0297 (TECPR2, KIAA0297, KIAA0329)
• telomerase protein component 1 (TEP1, p240, p80 telomerase homolog)
• THO complex subunit 3 (Tho3, TEX1 homolog, THOC3)
• transcription initiation factor TFIID subunit 5; p100TFIID; transcription initiation factor TFIID 100 kD subunit; TAF(II)100; TAFII-100; TAFII100 (TAF5, TAF2D)
• transducin beta-like protein 3; WD repeat-containing protein SAZD (TBL3 SAZD)
• transducin-like enhancer protein (ESG)
• tubby-related protein 4; tubby superfamily protein; tubby-like protein 4 (TULP4, KIAA1397, TUBL4, TUSP)
• U3 small nucleolar RNA-associated protein 15 homolog (UTP15)
• U3 small nucleolar RNA-associated protein 18 homolog; WD repeat-containing protein 50 (UTP18, WDR50, CDABP0061, CGI48)
• U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kD protein; WD splicing factor Prp4; hPrp4 (PRPF4)
• WD & tetratricopeptide repeats protein 1 (WDTC1, KIAA1037)
• WD repeat & FYVE domain containing protein 3 (autophagy-linked FYVE protein, Alfy, WDFY3, KIAA0993)
• WD repeat & FYVE domain-containing protein 1; FENS-1; phosphoinositide-binding protein 1; WD40- & FYVE domain-containing protein 1; zinc finger FYVE domain-containing protein 17 (WDFY1, KIAA1435, WDF1, ZFYVE17)
• WD repeat & FYVE domain-containing protein 2; WD40- & FYVE domain-containing protein 2; zinc finger FYVE domain-containing protein 22 (WDFY2, WDF2, ZFYVE22)
• WD repeat & HMG-box DNA-binding protein 1 (acidic nucleoplasmic DNA-binding protein 1, And-1, WDHD1, AND1)
• WD repeat & SOCS box-containing protein 1; WSB-1; SOCS box-containing WD protein SWiP-1 (WSB1, SWIP1)
• WD repeat & SOCS box-containing protein 2; WSB-2; CS box-containing WD protein (WSB2)
• WD repeat & SOF domain-containing protein 1; DDB1- & CUL4-associated factor 13 (DCAF13, WDSOF1, HSPC064)
• WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1, WD40 repeat protein interacting with phosphoinositides of 49 kD, WIPI 49 kD, Atg18 protein homolog, WIPI1, WIPI49)
• WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2, WIPI49-like protein 2, WIPI2)
• WD repeat domain phosphoinositide-interacting protein 3; WIPI-3; WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein (WDR45B, WDR45L, WIPI3)
• WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4, WD repeat protein 45, WDR45, WDRXI4, WIPI4, JM5)
• WD repeat protein 16 (WD40-repeat protein up-regulated in HCC, WDR16, WDRPUH)
• WD repeat protein 19 (WDR19, KIAA1638)
• WD repeat protein 21B; DDB1- & CUL4-associated factor 4-like protein 1 (WDR21B, LOC285429, DCAF4L1)
• WD repeat protein 21C (WDR21C, DCAF4L2)
• WD repeat protein 24 (WDR24)
• WD repeat protein 25 (WDR25)
• WD repeat protein 41 (WDR41)
• WD repeat protein 43
• WD repeat protein 44 (rabphilin-11 WDR44)
• WD repeat protein 47 (WDR47, KIAA0893)
• WD repeat protein 48 (WD repeat endosomal protein, p80, WDR48, KIAA1449)
• WD repeat protein 49 (WDR49)
• WD repeat protein 51A (WDR51A, POC1A)
• WD repeat protein 51B (WDR51B, POC1B)
• WD repeat protein 53 (WDR53)
• WD repeat protein 54 (WDR54)
• WD repeat protein 55 (WDR55)
• WD repeat protein 57; Prp8-binding protein; hPRP8BP; U5 snRNP-specific 40 kD protein; 38 kD-splicing factor (WDR57, SNRNP40, PRP8BP, SFP38)
• WD repeat protein 58 (THO complex subunit 6 homolog, THOC6, WDR58, PSEC0006)
• WD repeat protein 59 (WDR59, KIAA1923, FP977)
• WD repeat protein 5B (WDR5B)
• WD repeat protein 60 (WDR60)
• WD repeat protein 61 (meiotic recombination REC14 protein homolog, WDR61)
• WD repeat protein 62 (WDR62, C19orf14)
• WD repeat protein 63 (Testis development protein NYD-SP29, WDR63)
• WD repeat protein 65 (WDR65)
• WD repeat protein 71 (proteasomal ATPase-associated factor 1, protein G-16, WDR71, PAAF1)
• WD repeat protein 72 (WDR72)
• WD repeat protein 74 (NOP seven-associated protein 1, WDR74, NSA1)
• WD repeat protein 75 (WDR75)
• WD repeat protein 76 (WDR76)
• WD repeat protein 78 (WDR78)
• WD repeat protein 79; telomerase Cajal body protein 1; WD40 repeat-containing protein encoding RNA antisense to p53 (WRAP53 TCAB1 WDR79)
• WD repeat protein 81 (WDR81)
• WD repeat protein 82 (WDR82)
• WD repeat protein 88 (PQQ repeat & WD repeat-containing protein, WDR88, PQWD)
• WD repeat protein 89 (WDR89, C14orf150, MST050)
• WD repeat, SAM & U-box domain-containing protein 1 (WDSUB1, WDSAM1)
• WD repeat-containing protein 10; intraflagellar transport protein 122 homolog (IFT122, SPG, WDR10, WDR140)
• WD repeat-containing protein 11; bromodomain & WD repeat-containing protein 2; WD repeat-containing protein 15 (WDR11, BRWD2, KIAA1351, WDR15)
• WD repeat-containing protein 12; ribosome biogenesis protein WDR12 (WDR12)
• WD repeat-containing protein 13 (WDR13)
• WD repeat-containing protein 17 (WDR17)
• WD repeat-containing protein 18 (WDR18)
• WD repeat-containing protein 1; actin-interacting protein 1; AIP1; NORI-1 (WDR1)
• WD repeat-containing protein 20; protein DMR (WDR20)
• WD repeat-containing protein 22; DDB1- & CUL4-associated factor 5; breakpoint cluster region protein 2; BCRP2 (DCAF5, BCRG2, KIAA1824, WDR22)
• WD repeat-containing protein 23; DDB1- & CUL4-associated factor 11 (DCAF11, WDR23, GL014, PRO2389)
• WD repeat-containing protein 26; CUL4- & DDB1-associated WDR protein 2; myocardial ischemic preconditioning up-regulated protein 2 (WDR26, CDW2, MIP2, PRO0852)
• WD repeat-containing protein 27 (WDR27)
• WD repeat-containing protein 3 (WDR3)
• WD repeat-containing protein 31 (WDR31)
• WD repeat-containing protein 32 (WDR32, DCAF10)
• WD repeat-containing protein 33; WD repeat-containing protein WDC146 (WDR33, WDC146)
• WD repeat-containing protein 34 (WDR34)
• WD repeat-containing protein 35 (WDR35 KIAA1336)
• WD repeat-containing protein 36; T-cell activation WD repeat-containing protein; TA-WDRP (WDR36)
• WD repeat-containing protein 37 (WDR37 KIAA0982)
• WD repeat-containing protein 39; cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1, WDR39)
• WD repeat-containing protein 40A; centrosome-related protein TCC52 (WDR40A, DCAF12, KIAA1892)
• WD repeat-containing protein 40B (WDR40B, DCAF12L1)
• WD repeat-containing protein 40C (WDR40C, DCAF12L2)
• WD repeat-containing protein 42A (WDR42A, DCAF8, H326)
• WD repeat-containing protein 42B (WDR42B, DCAF8L1)
• WD repeat-containing protein 42C (WDR42C, DCAF8L2)
• WD repeat-containing protein 46; WD repeat-containing protein BING4 (WDR46, BING4, C6orf11, FP221)
• WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (WDR4)
• WD repeat-containing protein 52 (WDR52)
• WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)
• WD repeat-containing protein 6 (WDR6)
• WD repeat-containing protein 64 (WDR64)
• WD repeat-containing protein 66 (WDR66)
• WD repeat-containing protein 67; TBC1 domain family member 31 (TBC1D31, WDR67)
• WD repeat-containing protein 69; dynein assembly factor with WDR repeat domains 1; outer row dynein assembly protein 16 homolog (DAW1, WDR69)
• WD repeat-containing protein 70 (WDR70)
• WD repeat-containing protein 73 (WDR73)
• WD repeat-containing protein 7; TGF-beta resistance-associated protein TRAG; Rabconnectin-3 beta (WDR7, KIAA0541, TRAG)
• WD repeat-containing protein 8 (WDR8, WRAP73)
• WD repeat-containing protein 85; diphthamide biosynthesis protein 7 (DPH7, C9orf112, WDR85)
• WD repeat-containing protein 86 (WDR86)
• WD repeat-containing protein 87 (testis development protein NYD-SP11, WDR87)
• WD repeat-containing protein 90 (WDR90, C16orf15, C16orf16, C16orf17, KIAA1924)
• WD repeat-containing protein 91 (WDR91)
• WD repeat-containing protein 92 (WD repeat-containing protein monad, WDR92)
• WD repeat-containing protein 93 (WDR93)
• WD repeat-containing protein 9; bromodomain & WD repeat-containing protein 1 (BRWD1, C21orf107, WDR9)
• WD repeat-containing protein C10orf79 (WDR96)
• WD repeat-containing protein C2orf44 (C2orf44)
• WD repeat-containing protein KIAA1875 (KIAA1875)
• WD repeat-containing protein LOC51057 (WDPCP)
• WD repeat-containing protein mio (MIOS)
• zinc finger protein 106 homolog; zinc finger protein 474 (ZNF474, Zfp-106, ZFP106)