WD repeat protein 19 (WDR19, KIAA1638)

Structure

• contains 6 TPR repeats
• contains 6 WD repeats

Alternative splicing

named isoforms=3

Expression

• some isoforms are tissue-specific
• expressed in the prostate > cerebellum,pituitary gland, fetal lung, pancreas

in normal prostate, expressed in both basal & luminal epithelial cells

no expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes within prostate

induced by androgens

Pathology

• uniform expression in prostate adenocarcinoma cells
• expression increased 3-fold in an androgen-stimulated androgen-sensitive prostate adenocarcinoma cell line

More general terms

• WD repeat protein family

Database

• OMIM: https://mirror.omim.org/entry/608151
• UniProt: http://www.uniprot.org/uniprot/Q8NEZ3.html