lipopolysaccharide-responsive & beige-like anchor protein; Beige-like protein; CDC4-like protein (LRBA, BGL, CDC4L, LBA)

Function

• may be involved in coupling signal transduction & vesicle trafficking to enable polarized secretion &/or membrane deposition of immune effector molecules (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 1 BEACH domain
• contains 6 WD repeats

Compartment

• cell membrane; single-pass membrane protein (putative)
• endoplasmic reticulum (putative)
• Golgi, trans-Golgi network (putative)
• lysosome

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• induced by bacterial lipopolysaccharides (LPS)

More general terms

• WD repeat protein family
• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=987
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:987
• OMIM: https://mirror.omim.org/entry/606453
• UniProt: http://www.uniprot.org/uniprot/P50851.html