BTB/POZ domain-containing protein KCTD3 (renal carcinoma antigen NY-REN-45, KCTD3)

Structure

• contains 1 BTB domain (POZ domain)
• contains 5 WD repeats

Alternative splicing

namedd isoforms=3

Expression

• broadly expressed in normal tissues

Pathology

• reacts with sera from 5-25 % of cancer patients but not with sera from normal donors
• 75% of renal cancer patients have antibodies against one or a panel of these antigens

More general terms

• BTB/POZ domain containing protein
• WD repeat protein family

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y597.html