polycomb protein EED; hEED; WD protein associating with integrin cytoplasmic tails 1; WAIT-1 (EED)

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Function

polycomb group (PcG) protein
component of the PRC2/EED- EZH2 complex, which methylates Lys-9 & Lys-27 of histone H3, leading to transcriptional repression of the affected target gene
the PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems
genes repressed by the include HOXC8, HOXA9, MYT1 & CDKN2A
interacts with MLL (putative)
component of the PRC2/EED-EZH2 complex
interacts with HDAC, HDAC2, histone H1 & YY1
may interact with ITGA4, ITGAE & ITGB7
may interact with the MA protein of HIV-1

named isoforms=3
additional isoforms may be produced by alternative initiation, both from non-canonical start codons upstream of the initiator Met displayed & from other canonical start codons downstream of that displayed; the precise sites of translation initiation have not been unambiguously identified

expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus & uterus.
expression peaks at the G1/S phase boundary
expression is induced by E2F1, E2F2 & E2F3