histone deacetylase 2 (HDAC2)

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Function

Structure

Compartment

nucleus

Expression

  • widely expressed
  • lower levels of expression in brain & lung

Pathology

Pharmacology

More general terms

Component of

References

  1. UniProt http://www.uniprot.org/uniprot/Q92769.html
  2. Brehm et al Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9468139
  3. Magnaghi-Jaulin L et al Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-5, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9468140
  4. 4.0 4.1 Guan J-S et al. HDAC2 negatively regulates memory formation and synaptic plasticity Nature 2009 May 7; 459:55. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19424149
  5. Graff J et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012 Mar 8; 483:222 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22388814

Database