histone deacetylase 2 (HDAC2)
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Function
- see histone deacetylase
- deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
- forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 & N-COR
- interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1
- interacts with the non-histone region of H2AFY
- part of the core histone deacetylase complex (HDAC complex)
- component of BHC histone deacetylase complex
- component of a mSin3A corepressor complex
- part of a complex containing the core histones H2A, H2B, H3 & H4, DEK & unphosphorylated DAXX
- part of a complex containing ATR & CHD4
- forms a heterologous complex at least with YY1
- interacts with ATR, DNMT1, MINT, HDAC7, HDAC10, HCFC1, NRIP1, MJD2A/JHDM3A, SAP30, SETDB1 & SUV39H1
- interacts with the non-histone region of H2AFY
- interacts with PELP1
- interacts with CBFA2T3
- interacts with SAP30L
Structure
- belongs to the histone deacetylase family, type 1 subfamily
Compartment
Expression
- widely expressed
- lower levels of expression in brain & lung
Pathology
- in mice, HDAC2 impairs memory; inhibition of HDAC2 with vorinostat (Zolinza, SAHA) enhances memory[4]
- higher levels of HDAC2 are found in hippocampus from Alzheimer's disease patients
Pharmacology
- vorinostat (Zolinza, SAHA) inhibits HDAC2
- divalproex inhibits histone deacetylase (HDAC1, HDAC2, HDAC3 ?)
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q92769.html
- ↑ Brehm et al Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597-601, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9468139
- ↑ Magnaghi-Jaulin L et al Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601-5, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9468140
- ↑ 4.0 4.1 Guan J-S et al. HDAC2 negatively regulates memory formation and synaptic plasticity Nature 2009 May 7; 459:55. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19424149
- ↑ Graff J et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012 Mar 8; 483:222 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22388814