histone deacetylase 10 (HDAC10)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• interacts with HDAC2, HDAC3 & NCOR2

Structure

• belongs to the histone deacetylase family, type 2 subfamily

Compartment

• cytoplasm, nucleus
• excluded from nucleoli

Alternative splicing

named isoforms=4

Expression

• ubiquitous
• high expression in liver, spleen, pancreas & kidney

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• histone deacetylase

Database

• UniProt: http://www.uniprot.org/uniprot/Q969S8.html
• OMIM: https://mirror.omim.org/entry/608544
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83933