premature termination codon
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Introduction
The occurrence of a termination codon within mRNA in an upstream location rendering translation of a truncated protein. These premature termination codons are discriminated from true termination codons by downstream cis-elements, such as exon-exon junctions.
More general terms
References
- ↑ Lykke-Anderson J et al Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103:1121-31, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11163187