chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kD protein; Mi2-beta (CHD4)

Function

• component of the histone deacetylase NuRD complex
• interacts directly with IKFZ1 in the NuRD complex
• interacts with TRIM27
• interacts with KLF1
  • interaction depends on sumoylation of KLF1, & leads to its transcriptional repression (putative)
• interacts with ZGPAT
• interacts with PCNT
• part of a complex containing ATR & HDAC2
• phosphorylated upon DNA damage, probably by ATM or ATR

ATP + H2O = ADP + phosphate

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 2 chromo domains
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 2 PHD-type Zn+2 fingers

Compartment

• nucleus, cytoplasm, cytoskeleton, centrosome
• associates with centrosomes in interphase

Alternative splicing

named isoforms=2

Pathology

• one of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis

More general terms

• chromodomain-helicase-DNA-binding protein
• zinc finger protein
• phosphoprotein

Component of

• nucleosome remodeling & histone deacetylation (NuRD) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1108
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1108
• OMIM: https://mirror.omim.org/entry/603277
• UniProt: http://www.uniprot.org/uniprot/Q14839.html