zinc finger protein RFP; Ret finger protein; tripartite motif-containing protein 27; RING finger protein 76 (TRIM27, RFP, RNF76)

Function

• has transcriptional repressor activity by cooperating with EPC1
• induces apoptosis by activating Jun N-terminal kinase & p38 kinase & also increases caspase-3-like activity independently of mitochondrial events
• may function in male germ cell development
• has DNA-binding activity & preferentially binds double-stranded DNA (putative)
• homomultimerizes
• interacts with PML, EIF3S6, EPC1, CHD4 & EID1

Structure

• the coiled-coil region mediates interaction with EPC1 & CHD4
• the B box & coiled-coil domains mediate interaction with PML
• the B box & the distal coiled-coil domains mediate homomultimerisation
• the B30.2 domain mediates interaction with EIF3S6
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

• nucleus (putative). cytoplasm
• nuclear or cytoplasmic depending on the cell type (putative)
• colocalized with PML & EIF3S6 in nuclear bodies

Alternative splicing

named isoforms=2; alpha, beta

Expression

• expressed in testis namely within the seminiferous tubules

Pathology

• chromosomal translocation t(6;10)(p21.3;q11.2) involving TRIM27 with RET is a cause of thyroid papillary carcinoma; the translocation generates RFP/RET & delta RFP/RET oncogenes

More general terms

• DNA-binding protein
• proto oncogene protein
• ring finger protein

Additional terms

• Ret finger protein-like 1; RING finger protein 78 (RFPL1, RFPL1L, RNF78)
• Ret finger protein-like 2; RING finger protein 79 (RFPL2, RNF79)
• Ret finger protein-like 3 (RFPL3)

Database

• UniProt: http://www.uniprot.org/uniprot/P14373.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5987
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5987
• OMIM: https://mirror.omim.org/entry/188550
• OMIM: https://mirror.omim.org/entry/602165