EP300-interacting inhibitor of differentiation 1 (EID-1, E1A-like inhibitor of differentiation 1, CREBBP/EP300 inhibitory protein 1, 21 kD pRb-associated protein, EID1, C15orf3, CRI1, RBP21, PNAS-22, PTD014)
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Function
- interacts with RB1 & EP300
- acts as a repressor of MYOD1 transactivation
- inhibits EP300 & CBP histone acetyltransferase activity
- role in coupling cell cycle exit to transcriptional activation of genes required for cellular differentiation
- candidate coinhibitory factor for NR0B2
- interacts via its LXCXE motif with pocket region of RB1
- interacts with EP300, NR0B2 & TRIM27
- ubiquitinated in U-2OS osteosarcoma cells & is rapidly degraded by proteasome as cells exit the cell cycle
- inhibition of MYOD1 may be partly due to the ability of EID1 to bind & inhibit EP300 histone acetyltransferase activity
Compartment
Alternative splicing
named isoforms=2
Expression
- widely expressed
- expressed in heart, skeletal muscle, pancreas, brain, testis > placenta, peripheral blood leukocyte
- barely detectable in lung
- expression decreased with development in cardiac ventricular tissue, but remains high in adult atrial tissue
- in human skeletal myocytes, expression decreased during myogenic differentiation (at protein level)
- down-regulated in differentiating U937 leukemia cells
Pathology
- weakly expressed in lung carcinoma A549 & various leukemia cell lines