osteosarcoma (osteogenic sarcoma)
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Classification
(WHO)
- central (medullary)
- conventional central osteosarcoma
- chondroblastic osteosarcoma
- fibroblastic osteosarcoma
- osteoblastic osteosarcoma
- telangiectatic osteosarcoma
- intraosseous well-differentiated (low grade) osteosarcoma
- small cell osteosarcoma
- conventional central osteosarcoma
- surface (peripheral)
- parosteal well differentiated (low grade) osteosarcoma
- perosteal osteosarcoma, low to intermediate grade
- high grade surface osteosarcoma
Epidemiology
- occurs predominantly in children & young adults.
- most common sites are metaphyses of long bones
Genetics
Clinical manifestations
- typically affect the metaphyses of the long bones
- ~50% arise in the femur
- ~80% of these adjacent to the knee
- usually occur with few symptoms
Diagnostic procedures
- bone biopsy* prior to surgical intervention for fracture
* biopsy result will guide surgical approach
Radiology
- spiculated appearance
- Codman triangles
- intramedullary sclerosis
Complications
- pulmonary metastases from chondroblastic sarcoma[3] (images)
- metaphyseal fracture in adolescent or young adult
Management
- see[1]
- cryosurgery
More general terms
More specific terms
- extraosseous osteogenic sarcoma
- osteosarcoma [RB1 mutation]
- osteosarcoma [TP53/ARG248GLN]
- osteosarcoma [TP53/SER241PHE]
- retinoblastoma-related osteosarcoma
References
- ↑ 1.0 1.1 WHO Classification Tumours of Soft Tissue and Bone Fletcher, Unni & Mertens Eds. IARC Press 2002
- ↑ NEJM Knowledge+ Question of the Week. Jan 8, 2018 https://knowledgeplus.nejm.org/question-of-week/4923/
- ↑ 3.0 3.1 Mamdani H, Grethlein SJ Pulmonary Metastases from Chondroblastic Osteosarcoma. N Engl J Med 2018; 378:1429. April 12, 2018 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29641960 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1711874
- ↑ National Cancer Institute - Osteosarcoma/Bone Fibrous Histiocytoma Treatment http://www.nci.nih.gov/cancertopics/pdq/treatment/osteosarcoma/healthprofessional
Patient information
osteosarcoma patient information