fibroblast
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Introduction
Fibroblasts from papllary dermis & reticular dermis are different[1]
Histology
- papillary fibroblasts appear lean & spindle-shaped in culture
- reticular fibroblasts appear more square & stretched and also express more alpha-smooth muscle actin
Pathology
- it has been proposed that skin aging is caused by the loss of papillary fibroblasts (see skin aging)
Genetics
- reticular fibroblasts were more prone to overexpress genes in pathways controlling smooth muscle contraction, cytoskeletal organization, cell motility, & neuronal development
- matrix Gla protein is almost exclusively expressed in the reticular dermis
- papillary fibroblasts were more prone to overexpress genes related to complement activation, host defense, & immune response
More general terms
More specific terms
References
- ↑ 1.0 1.1 Janson DG et al. Different gene expression patterns in human papillary and reticular fibroblasts. J Invest Dermatol 2012 Nov; 132:2565 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22696053