matrix Gla protein; MGP; cell growth-inhibiting gene 36 protein (MGP, MGLAP, GIG36)

Function

• associates with the organic matrix of bone & cartilage
• thought to act as an inhibitor of bone formation
• requires vitamin K-dependent gamma-carboxylation for its function

Structure

• belongs to the osteocalcin/matrix Gla protein family
• contains 1 Gla (gamma-carboxy-glutamate) domain

Compartment

secreted

Pathology

• defects in MGP are the cause of Keutel syndrome

More general terms

• matrix protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4256
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4256
• OMIM: https://mirror.omim.org/entry/154870
• OMIM: https://mirror.omim.org/entry/245150
• UniProt: http://www.uniprot.org/uniprot/P08493.html