osteocalcin; bone GLA protein; gamma-carboxyglutamic acid-containing protein (BGP, BGLAP)

Function

• vitamin K-dependent bone protein
• major non collagenous protein in bone
• constitutes 1-2% of the total bone protein
• the exact biological function of osteocalcin is not known, but the 3 gamma-carboxyglutamate residues confer on it strong binding of Ca+2 & hydroxyapatite

Structure

• belongs to the osteocalcin/matrix Gla protein family
• contains 1 Gla domain (gamma-carboxyglutamate) domain

Compartment

• secreted osteocalcin is mostly incorporated into bone matrix, with some escaping into the blood

Expression

• synthesized exclusively by non proliferating osteoblasts in a mineralizing extracellular matrix

Pharmacology

• warfarin, because it inhibits formation of gamma-carboxyglutamate residues inhibits maturaton of osteocalcin

More general terms

• secreted peptide

Additional terms

• osteocalcin in serum

Database

• UniProt: http://www.uniprot.org/uniprot/P02818.html
• UniProt: http://www.uniprot.org/uniprot/P84351.html
• OMIM: https://mirror.omim.org/entry/112260