peptidylprolyl cis-trans isomerase A-like 4B (PPIase A-like 4B, chromosome 1-amplified sequence 2, COAS-2, cyclophilin homolog overexpressed in liver cancer, PPIAL4B COAS2)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides (putative)

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIase A subfamily
• contains 1 PPIase cyclophilin-type domain

Compartment

cytoplasm (putative)

Expression

• highly expressed in brain, ovary & mammary gland
• moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine & spleen
• weakly expressed in skeletal muscle, liver & stomach

Pathology

• expressed in pleomorphic & undifferentiated liposarcomas, osteosarcomas & breast carcinomas

Genetics

• one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1
• expression studies do not distinguish between PPIAL4B & PPIAL4

More general terms

• peptidyl-prolyl cis/trans isomerase (PPIase) or rotamase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1640
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6535
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6535
• OMIM: https://mirror.omim.org/entry/608608
• UniProt: http://www.uniprot.org/uniprot/Q9Y536.html