peptidylprolyl cis-trans isomerase A-like 4; PPIase A-like 4; chromosome 1-amplified sequence 2; COAS-2 (PPIAL4, COAS2, PPIAL4A)

Function

• PPIases accelerate the folding of proteins
• catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (putative)

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIase A subfamily
• contains 1 PPIase cyclophilin-type domain

Compartment

cytoplasm (putative)

Expression

• expressed in brain, ovary & mammary gland > lung, salivary gland, kidney, skin, adipose tissue, intestine & spleen > skeletal muscle, liver & stomach

Pathology

• expressed in pleomorphic & undifferentiated liposarcomas, osteosarcomas & breast carcinomas

Genetics

• gene is 1 of 7 related genes or pseudogenes found in a cluster on chromosome 1, thought to result from gene duplication

More general terms

• cyclophilin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6445
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7289
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7302
• OMIM: https://mirror.omim.org/entry/608608