checkpoint kinase 2; serine/threonine protein kinase Chk2; homolog of S. cerevisiae Rad53; Cds1 (CHEK2, CHK2, RAD53)

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Function

Cofactor: Mg+2

Structure

Compartment

Alternative splicing

named isoforms=12

Expression

Pathology

Laboratory

Notes

some isoforms may be catalytically inactive

More general terms

References

  1. OMIM https://mirror.omim.org/entry/604373
  2. Matsuoka S et al Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282:1893-7, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9836640
  3. Hirao A et al DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287:1824-7, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10710310
  4. Bell DW et al Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286:2528-31, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10617473
  5. UniProt http://www.uniprot.org/uniprot/O96017.html
  6. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/CHEK2ID312.html
  7. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CHEK2
  8. NIEHS-SNPs http://egp.gs.washington.edu/data/chek2/

Database