DNA double strand break

Introduction

also see DNA double-strand break repair

Pathology

• aging & Alzheimer disease are associated with an accumulation of neuronal DNA double-strand breaks
• DNA double strand breaks accompany neuronal activity in regions remode chromatin during the process of learning
• repair of the damage by resting may help to consolidate new memories, but as editorialists note
• DNA double-strand repair is not free of errors
• amyloid beta increases neuronal DNA double-strand breaks, possibly by stimulating excessive activity to process information in damaged systems, & may exacerbate errors in DNA repair

Management

• blocking excitatory amino-acid pathways may facilitate the recuperative effect of resting

More general terms

• biochemistry

Additional terms

• DNA double-strand break repair