tumor suppressor gene or anti-oncogene

Introduction

Tumor suppressor genes are involved in cell cycle checkpoints. Inactivation of tumor suppressor genes usually occurs by loss of one allele followed by a point mutation in the remaining allele. Homozygous deletions are rare.

More general terms

• gene

More specific terms

• CDKN2C gene
• CYLD1 (cylindromatosis) gene
• Deleted in Colon Carcinoma [DCC] tumor suppressor gene
• deleted in neuroblastoma 5
• drosophila discs large [dlg] gene
• familial adenomatous polyposis [FAP] gene
• KCNRG gene
• malignant transformation suppression-1 (MTS1) gene; suppressor of anchorage independence-1 gene; transformation suppressor-1 (TFS-1) gene
• MMAC1 or PTEN gene
• multiple tumor suppressor-1 (MTS1); INK4; CDKN2A gene
• multiple tumor suppressor-2 (MTS2) gene; CDKN2B
• Mutated in Colon Carcinoma [MCC] tumor suppressor gene
• neurofibromatosis type-1 gene or NF1 gene
• neurofibromatosis type-2 gene or NF2 gene
• p53 gene
• p63 gene
• p73 gene
• ras GAP gene
• retinoblastoma [Rb] gene (Rb1)
• SAS gene
• WAF1 gene, PIC1, CIP1, SDI1
• Wilms tumor gene, WAGR gene or wt1

Additional terms

• anti-oncoprotein (tumor suppressor protein)