WAF1 gene, PIC1, CIP1, SDI1
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Introduction
p53-inducible gene. The rate of WAF1 gene mutations is very low; WAF1 inactivation in tumors may occur largely via aberrations in transcriptional regulation by p53[4]. However, a point mutation in WAF1 from a bladder carcinoma that produces a stop codon is described[4].
More general terms
References
- ↑ Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993 Nov 19;75(4):805-16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8242751
- ↑ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8242752
- ↑ Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376-80. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7973727
- ↑ 4.0 4.1 4.2 Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7677168
- ↑ Nature Genet 15: 1997