Protein OS-9 (amplified in osteosarcoma 9, OS9)

Function

• role in the ER-associated degradation of misfolded glycoproteins

Structure

• belongs to the OS-9 family
• contains 1 PRKCSH domain

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• isoform 2 major isoform detected in all cell types examined

Pathology

• found in all tumor cell lines analyzed
• amplified in sarcomas
• highly expressed in osteosarcoma OSA-CL & rhabdomyosarcoma RH30 cell lines

More general terms

• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q13438.html