A disintegrin & metalloproteinase with thrombospondin type 1 motif 19; ADAMTS-19; ADAM-TS 19; ADAM-TS19 (ADAMTS19)
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Function
- precursor is cleaved by a furin endopeptidase
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure
- the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
- dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
- contains 1 disintegrin domain
- contains 1 peptidase M12B domain
- contains 1 PLAC domain
- contains 5 TSP type-1 domains
Compartment
Expression
- expressed in fetal lung
- not expressed in any adult tissues examined
Pathology
- expression detected in an osteosarcoma cDNA library