nuclear receptor 0B2 (nuclear receptor subfamily 0 group B member 2, orphan nuclear receptor SHP, small heterodimer partner, NR0B2, SHP)

Function

• acts as a negative regulator of receptor-dependent signaling
• inhibits transactivation of nuclear receptor with which it interacts
• interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG, HNF4A

Structure

• belongs to the nuclear hormone receptor family, NR0 subfamily

Compartment

nucleus

Expression

expressed in liver > heart, pancreas

Pathology

• defects in NR0B2 associated with early-onset obesity

More general terms

• nuclear hormone receptor family

Additional terms

• familial obesity

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8431
• OMIM: https://mirror.omim.org/entry/601665
• OMIM: https://mirror.omim.org/entry/604630
• UniProt: http://www.uniprot.org/uniprot/Q15466.html