nuclear receptor subfamily 1 group I member 3; constitutive androstane receptor; CAR; constitutive activator of retinoid response; constitutive active response; orphan nuclear receptor MB67 (NR1I3, CAR)

Function

• binds & transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta-2 & alcohol dehydrogenase 3 genes
• transactivates both the phenobarbital responsive element module of the human CYP2B6 gene & the CYP3A4 xenobiotic response element
• heterodimer of NR1I3 & RXR
• interacts with PSMC4

Structure

• composed of a short N-terminal domain followed by the DNA binding, hinge, & ligand binding/dimerization domains
• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in liver
• induced by dexamethasone

More general terms

• steroid receptor
• nuclear hormone receptor NR1 subfamily
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/603881
• UniProt: http://www.uniprot.org/uniprot/Q14994.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9970