cytochrome P450 2B6 (cytochrome P450 2B1, phenobarbital-inducible, CYP2B6)
Jump to navigation
Jump to search
Function
- NADPH-dependent electron transport pathway
- oxidizes a variety of structurally unrelated compounds
- phosphorylation decreases enzyme activity
- inducers
- substrates
Compartment
membrane-bound, endoplasmic reticulum
Expression
- expressed in liver, lung & heart right ventricle
- induced by phenobarbital
Polymorphism
- polymorphisms can lead to accumulation of efavirenz & persistence after discontinuation[2]
Laboratory
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P20813.html
- ↑ 2.0 2.1 Ribaudo HJ et al, Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: An adult AIDS Clinical Trial Group Study. Clin Infect Dis 2006; 42:401 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16392089
Nolan D et al, Efavirenz and CYP2B6 polymorphism: Implications for drug toxicity and resistance. Clin Infect Dis 2006; 42:408 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16392090 - ↑ Cytochrome P450 Allele Nomenclature committee, CYP2B6 alleles http://www.cypalleles.ki.se/cyp2b6.htm