nuclear hormone receptor family
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Function
- ligand-activated transcription factors that regulate eukaryotic gene expression & affect cellular proliferation & differentiation in target tissues
- transcription factor activity is modulated by bound coactivator & corepressor proteins
- cytoplasmic anchoring facilitated by heat shock proteins
- steroid receptors are nuclear hormone receptors
* see figure A & figure B ligands for nuclear hormone receptors
More general terms
More specific terms
- bile acid receptor; nuclear receptor subfamily 1 group H member 4; farnesoid X-activated receptor; farnesol receptor HRR-1; retinoid X receptor-interacting protein 14; RXR-interacting protein 14 (NR1H4, BAR, FXR, HRR1, RIP14)
- ecdysone receptor
- nuclear hormone receptor NOR-1 (orphan nuclear receptor NR4A3, neuron-derived orphan receptor 1, mitogen-induced nuclear orphan receptor,nuclear receptor subfamily 4 group A member 3, NR4A3, CHN, CSMF, NOR1, TEC)
- nuclear hormone receptor NR1 subfamily
- nuclear hormone receptor NR2 subfamily
- nuclear hormone receptor NR3 subfamily
- nuclear hormone receptor NR4 subfamily
- nuclear hormone receptor NR5 subfamily
- nuclear receptor 0B2 (nuclear receptor subfamily 0 group B member 2, orphan nuclear receptor SHP, small heterodimer partner, NR0B2, SHP)
- orphan nuclear receptor NR1D2; nuclear receptor subfamily 1 group D member 2; Rev-erb-beta; EAR-1R; rev-erbA-alpha-related receptor; orphan nuclear hormone receptor BD73; rev-erb (NR1D2, RVR)
- orphan nuclear receptor NR2E1 (nuclear receptor subfamily 2 group E member 1, nuclear receptor TLX, tailless homolog, Tll, hTll, NR2E1, TLX)
- orphan nuclear receptor NR6A1 (nuclear receptor subfamily 6 group A member 1, germ cell nuclear factor, GCNF, retinoid receptor-related testis-specific receptor, RTR, NR6A1, GCNF)
- photoreceptor-specific nuclear receptor (retina-specific nuclear receptor, nuclear receptor subfamily 2 group E member 3, NR2E3, PNR, RNR)
- steroid receptor
References
- ↑ Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 704
- ↑ Binart N, Chambraud B, Levin JM, Garnier J, Baulieu EE. A highly charged sequence of chick hsp90: a good candidate for interaction with steroid receptors. J Steroid Biochem. 1989;34(1-6):369-74. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2626030
- ↑ Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR. The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors. Mol Endocrinol. 1992 Jan;6(1):3-7. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1738368